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Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 330-335 doi: 10.1007/s11684-016-0459-6
The enhancer of zeste 2 polycomb repressive complex 2 subunit (Ezh2) is a histone-lysine N-methyltransferase enzyme that participates in DNA methylation. Ezh2 has also been reported to play crucial roles in stem cell proliferation and differentiation. However, the detailed expression profile of Ezh2 during mouse cochlear development has not been investigated. Here, we examined the spatiotemporal expression of Ezh2 in the cochlea during embryonic and postnatal development. Ezh2 expression began to be observed in the whole otocyst nuclei at embryonic day 9.5 (E9.5). At E12.5, Ezh2 was expressed in the nuclei of the cochlear prosensory epithelium. At E13.5 and E15.5, Ezh2 was expressed from the apical to the basal turns in the nuclei of the differentiating cochlear epithelium. At postnatal day (P) 0 and 7, the Ezh2 expression was located in the nuclei of the cochlear epithelium in all three turns and could be clearly seen in outer and inner hair cells, supporting cells, the stria vascularis, and spiral ganglion cells. Ezh2 continued to be expressed in the cochlear epithelium of adult mice. Our results provide the basic Ezh2 expression pattern and might be useful for further investigating the detailed role of Ezh2 during cochlear development.
关键词: polycomb repressive complex Ezh2 expression inner ear cochlea development
Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 231-241 doi: 10.1007/s11684-013-0253-7
Hepatocellular carcinoma (HCC) development is characterized by the presence of epigenetic alterations, including promoter DNA hypermethylation and post-translational modifications of histone, which profoundly affect expression of a wide repertoire of genes critical for cancer development. Emerging data suggest that deregulation of polycomb group (PcG) proteins, which are key chromatin modifiers repressing gene transcription during developmental stage, plays a causative role in oncogenesis. PcG proteins assemble into polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2) to impose the histone H3 lysine 27 trimethylation (H3K27me3) modification for repression. In this review, we will first recapitulate the mechanisms of two key epigenetic pathways: DNA methylation and histone modifications. Specifically, we will focus our discussion on the molecular roles of PcG proteins. Next, we will highlight recent findings on PcG proteins, their clinicopathological implication and their downstream molecular consequence in hepatocarcinogenesis. Last but not least, we will consider the therapeutic potential of targeting enhancer of zeste homolog 2 (EZH2) as a possible treatment for HCC. Improving our understanding on the roles of PcG proteins in hepatocarcinogenesis can benefit the development of epigenetic-based therapy.
关键词: liver cancer epigenetics histone modifications polycomb group proteins enhancer of zeste homolog 2 (EZH2)
GID complex regulates the differentiation of neural stem cells by destabilizing TET2
《医学前沿(英文)》 doi: 10.1007/s11684-023-1007-9
关键词: TET2 GID complex neural stem cells differentiation of neurons
Footholds optimization for legged robots walking on complex terrain
《机械工程前沿(英文)》 2023年 第18卷 第2期 doi: 10.1007/s11465-022-0742-y
关键词: footholds optimization legged robot complex terrain adapting hexapod robot locomotion control
Special issue: Reliability management of complex system
《工程管理前沿(英文)》 2021年 第8卷 第4期 页码 477-479 doi: 10.1007/s42524-021-0175-z
Independent cover meshless particle method for complex geotechnical engineering
Jianqiu WU, Yongchang CAI
《结构与土木工程前沿(英文)》 2018年 第12卷 第4期 页码 515-526 doi: 10.1007/s11709-017-0428-4
关键词: meshless method particle method independent cover CTM geotechnical engineering
Forecast method for used number of parts and components based on complex network
LIU Fu-yun, QI Guo-ning, YANG Qing-hai
《机械工程前沿(英文)》 2006年 第1卷 第4期 页码 479-484 doi: 10.1007/s11465-006-0064-5
关键词: complex network industrial component analytic expression forecast
Cationic organobismuth complex as an effective catalyst for conversion of CO
Xiaowen ZHANG, Weili DAI, Shuangfeng YIN, Shenglian LUO, Chak-Tong AU
《环境科学与工程前沿(英文)》 2009年 第3卷 第1期 页码 32-37 doi: 10.1007/s11783-008-0068-y
关键词: cationic organobismuth complex terminal epoxide carbon dioxide coupling cyclic carbonate
《能源前沿(英文)》 2022年 第16卷 第5期 页码 697-699 doi: 10.1007/s11708-022-0843-7
Redox reactions of iron and manganese oxides in complex systems
Jianzhi Huang, Huichun Zhang
《环境科学与工程前沿(英文)》 2020年 第14卷 第5期 doi: 10.1007/s11783-020-1255-8
关键词: Iron oxides manganese oxides reduction oxidation complex systems reaction kinetics and mechanisms
A driving pulse edge modulation technique and its complex programming logic devices implementation
Xiao CHEN,Dong-chang QU,Yong GUO,Guo-zhu CHEN
《信息与电子工程前沿(英文)》 2015年 第16卷 第12期 页码 1088-1098 doi: 10.1631/FITEE.1500111
关键词: Driving pulse edge modulation Switching voltage spike Complex programmable logic device (CPLD) Active gate drive
Percolation-based health management of complex traffic systems
《工程管理前沿(英文)》 2021年 第8卷 第4期 页码 557-571 doi: 10.1007/s42524-021-0174-0
关键词: traffic health health management critical infrastructure systems science and engineering
Research Efforts and Fruits of Complex Engineering Management
Ji-Shan He
《工程管理前沿(英文)》 2015年 第2卷 第1期 页码 1-1 doi: 10.15302/J-FEM-2015001
Alireza ARABHA NAJAFABADI, Farhad DANESHJOO, Hamid Reza AHMADI
《结构与土木工程前沿(英文)》 2020年 第14卷 第3期 页码 722-730 doi: 10.1007/s11709-020-0624-5
关键词: damage detection strain energy influence line complex bridges rotation displacement
郭宝柱
《中国工程科学》 2008年 第10卷 第3期 页码 25-30
大型复杂技术项目的管理者面对着两个重要的系统,即被研制的工程系统和项目所处的组织机构系统(包括项目团队)。系统工程是成功实现工程系统的方法和技术,它综合多种专业技术,通过分析、综合、试验和评价的反复迭代过程,开发出一个整体性能优化的系统。社会组织系统是开放的复杂巨系统。组织机构的整体能力对大型复杂技术项目管理和系统工程方法的效能具有决定性的影响。必须在组织机构管理中强调系统的观点和方法,核心问题是如何发挥人的积极性、形成强大的群体创造力。这正是系统复杂性研究中揭示系统微观因素对宏观规律的影响机制问题。
标题 作者 时间 类型 操作
Independent cover meshless particle method for complex geotechnical engineering
Jianqiu WU, Yongchang CAI
期刊论文
Forecast method for used number of parts and components based on complex network
LIU Fu-yun, QI Guo-ning, YANG Qing-hai
期刊论文
Cationic organobismuth complex as an effective catalyst for conversion of CO
Xiaowen ZHANG, Weili DAI, Shuangfeng YIN, Shenglian LUO, Chak-Tong AU
期刊论文
Amino acid promoted hydrogen battery system using Mn-pincer complex for reversible CO hydrogenation to
期刊论文
A driving pulse edge modulation technique and its complex programming logic devices implementation
Xiao CHEN,Dong-chang QU,Yong GUO,Guo-zhu CHEN
期刊论文
Multiple damage detection in complex bridges based on strain energy extracted from single point measurement
Alireza ARABHA NAJAFABADI, Farhad DANESHJOO, Hamid Reza AHMADI
期刊论文